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Home > Smart Living> Innovation > This stamp-sized chip could make covid-19 testing easier

This stamp-sized chip could make covid-19 testing easier

Developed by researchers in the US, this chip can deliver test results on a smartphone in less than an hour

Programmed magnetic nanobeads paired with an off-the-shelf cellphone and plug-in diagnostic tool can diagnose covid-19 in 55 minutes or less.
Programmed magnetic nanobeads paired with an off-the-shelf cellphone and plug-in diagnostic tool can diagnose covid-19 in 55 minutes or less. (Jeff Fitlow/Rice University)

Washington: Scientists have developed a stamp-sized chip that simplifies covid-19 testing, and delivers results on a smartphone in less than 55 minutes.

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The micro-fluidic chip developed by researchers from Rice University in the US measures the concentration of SARS-CoV-2 nucleocapsid (N) protein, a biomarker for covid-19, in blood serum from a standard finger prick.

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According to the research published in the journal ACS Sensors, the nanobeads bind to SARS-CoV-2 N protein in the chip and transport it to an electrochemical sensor that detects minute amounts of the biomarker.

The researchers noted that their process simplifies sample handling compared to swab-based PCR tests that are widely used to diagnose covid-19 and need to be analysed in a laboratory.

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"What's great about this device is that it doesn't require a laboratory," said Rice University mechanical engineer Peter Lillehoj.

"You can perform the entire test and generate the results at the collection site, health clinic or even a pharmacy. The entire system is easily transportable and easy to use," he said in a statement.

The team, including Rice graduate student and lead author Jiran Li, took advantage of existing bio-sensing tools to develop simple diagnostics, like a micro-needle patch introduced last year to diagnose malaria.

The new tool relies on a slightly more complex detection scheme but delivers accurate, quantitative results in a short amount of time.

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To test the device, the researchers relied on donated serum samples from people who were healthy and others who were covid-19-positive.

They said a longer incubation yields more accurate results when using whole serum.

The team found that 55 minutes was an optimum amount of time for the micro-chip to sense SARS-CoV-2 N protein at concentrations as low as 50 picograms (billionths of a gram) per millilitre in whole serum.

The micro-chip could detect N protein in even lower concentrations, at 10 picograms per milliliter, in only 25 minutes by diluting the serum fivefold.

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Paired with a Google Pixel 2 phone and a plug-in potentiostat -- a device that controls voltage and measures resulting current -- it was able to deliver a positive diagnosis with a concentration as low as 230 picograms for whole serum.

"There are standard procedures to modify the beads with an antibody that targets a particular biomarker," Lillehoj said.

"When you combine them with a sample containing the biomarker, in this case SARS-CoV-2 N protein, they bond together," he added.

A capillary tube is used to deliver the sample to the chip, which is then placed on a magnet that pulls the beads towards an electrochemical sensor coated with capture antibodies.

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The beads bind to the capture antibodies and generate a current proportional to the concentration of biomarker in the sample.

The potentiostat reads that current and sends a signal to its phone app.

If there are no covid-19 biomarkers, the beads do not bind to the sensor and get washed away inside the chip.

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